Chronic SR Ca 2+ -ATPase Inhibition Causes Adaptive Changes in Cellular Ca 2+ Transport
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منابع مشابه
Chronic SR Ca -ATPase Inhibition Causes Adaptive Changes in Cellular Ca Transport
Phospholamban, the critical regulator of the cardiac SERCA2a Ca affinity, is phosphorylated at Ser and Thr during -adrenergic stimulation (eg, isoproterenol). To assess the impact of nonphosphorylatable phospholamban, a S16A, T17A double-mutant (DM) was introduced into phospholamban knockout mouse hearts. Transgenic lines expressing DM phospholamban at levels similar to wild types (WT) were ide...
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Of the many ongoing controversies regarding the workings of the sarcoplasmic reticulum (SR) in cardiac myocytes, two unresolved and interconnected topics are 1), mechanisms of calcium (Ca(2+)) wave propagation, and 2), speed of Ca(2+) diffusion within the SR. Ca(2+) waves are initiated when a spontaneous local SR Ca(2+) release event triggers additional release from neighboring clusters of SR r...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2003
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000066661.49920.59